A Deeper Look at Antioxidants
Medical professionals, nutritionists and the public at large
are increasingly aware of antioxidants and the essential role
they play in improving the body's ability to protect and repair
itself from the ravages of "free radicals." While free
radicals are created by the body during a cell's normal metabolic
functions they are also triggered by daily stresses including
excess sun exposure, smoking, environmental pollutants and alcohol.
The human body has its own capability to counteract most free
radicals through specific synthesized antioxidants absorbed in
our diet. But when outside toxins overload our bodies - our natural
defense systems fails to provide sufficient protection. This is
due to either an overwhelming production of free radicals or a
decrease of antioxidants in the body. Often this leads to "oxidative
stress" - a condition that occurs when free radicals overload
the human body's natural defense system. Oxidative stress causes
alterations in cell structure and function and cell death leading
to a wide variety of illnesses including heart disease, lung disease,
premature aging and cancer. Oxidative stress also damages DNA,
resulting in mutations that lead to a variety of cancers.
In order for antioxidants to be truly effective they must work
synergistically and in conjunction with the body's own ability
to protect, restore and repair itself from the ravages of free
radicals. By replicating the body's synergistic antioxidant cellular
defense system, the patented Thione Complex plays an integral
role in detoxifying free radicals and converting them into non-toxic
molecules. A singular antioxidant cannot regenerate itself. It
needs the help of specific synergistic antioxidants to do so.
This knowledge is becoming the basis for radical new drugs or
compositions that prevent or treat a variety of diseases. This
has become the foundation for Thione International's patented
How the Synergy Works
As one antioxidant molecule attacks and neutralizes one free
radical molecule, the antioxidant molecule becomes a free radical
itself. This new "antioxidant molecule turned free radical"
remains a toxic free radical until it is neutralized or regenerated
into an antioxidant again.
It is at this point that synergy becomes critical. Each "antioxidant
molecule turned free radical" must be regenerated by a specific
synergistic antioxidant, cellular enzyme or cofactor. It is those
antioxidants that form the basis for the Thione Complex
and assume the pivotal role in this process.
Such antioxidants are readily available from sources including
fruits, vegetables, liver, meats fowl and fish. Chicken is also
very high in antioxidants which may account for chicken soup's
legendary medicinal attributes. Although antioxidants are readily
available from these sources, the average individual does not
consume sufficient amounts to maintain or replenish the body's
antioxidants stores, leaving it unable to protect and repair itself
from excess free radicals.
II. Antioxidants and Aging
Through human and animal studies scientists have learned that
antioxidant deficiency in the elderly affects the aging process
and shortens life span. Additionally, the converse is also true,
by increasing antioxidants in the body, a healthy, longer life
can be achieved.
- Various clinical studies have documented that healthy, elderly
subjects have lower antioxidant levels than their younger counterparts.
- Vegetarians, whose life span is reportedly longer than carnivorous
individuals, have also been shown to have higher levels of antioxidants
in the body.
- Studies have shown that centenarians have higher levels of
antioxidants in their bodies than elderly individuals, a phenomenon
which may be the basis for their extended life span.
Low antioxidant levels place healthy, elderly subjects at a higher
risk of disease because of their decreased ability to deal with
everyday environmental stressors that increase free radicals.
Additionally, antioxidant repletion has been shown to help prevent
the vascular complications of diabetes and also improve control
of blood sugar. Antioxidants also reduce the risk of bad cholesterol,
atherosclerosis, heart disease and strokes.
III. Antioxidants and Clinical Entities
Studies show that clinical conditions associated with low antioxidant
levels in blood and affected tissues reveal that antioxidants
may be beneficial in at least decreasing or ameliorating the progress
of such diseases as Hepatitis C and HIV/AIDS.
Researchers at Stanford University have shown that restoring
antioxidant levels will diminish HIV replication. Clinically,
HIV+ individuals whose bodies were repleted with antioxidants
were shown to survive longer than those HIV+ subjects whose antioxidant
levels remained low.
- In chronic Hepatitis C, administration of antioxidants are
associated with a decrease in the viral load and an improvement
of the patient's liver tests.
- Many patients suffering from neurodegenerative disorders such
as Alzheimer's and Parkinson's diseases have been shown to have
low antioxidant levels - supplementation with synergistic antioxidants
may stop the clinical progression of these diseases.
- Likewise, macular degeneration, the leading cause of blindness
in adults, may be caused by free radicals from ultra-violet
radiation to the retinal pigment cells. Antioxidant levels in
these individuals have also been demonstrated to be low.
Thione International, Inc. is initiating clinical studies with
the Mayo Clinic (Scottsdale) and the University of Massachusetts
to prove the beneficial effect of its synergistic technology in
IV. Antioxidants and the Skin
While providing a protective barrier over the body's surface,
the skin is continuously exposed to various stressors including
ultraviolet radiation and atmospheric oxygen, which elicit harmful
free radical reactions.
It is hypothesized that radiation (i.e. excess sun exposure)
is responsible for setting off free radical reaction.
In order to combat free radicals, the skin, like other organs,
utilizes a well-developed antioxidant system, including reparative
and chain breaking antioxidants. These antioxidants synergistically
scavenge free radicals caused by ultraviolet radiation due to
the sun or forms of radiology.
Thione's line of skin and health care products containing the
Complex optimizes the synergistic antioxidant cycle to repair
radiation-damaged skin and help prevent photo aging. With the
addition of sunscreens, such preparations may enhance prevention
Since the Thione Complex also combats free radical species
generated by injuries such as chemical, radiation and thermal
burns (including post-cosmetic laser surgery), other wound healing
agents such as zinc compounds and epidermal cell growth factors
may be incorporated in these compositions.
Finally, cosmetic and dermatologic compositions which are used
as adjuncts in management of signs and symptoms of various disorders
that are also associated with local inflammatory conditions may
be supplemented with Thione's antioxidant cycle to ameliorate
Antioxidants play a key role in protecting and repairing the
body from the ravages of free radicals. While a diet high in fruits
and vegetables will certainly help replete the body of these critical
components, for those who do not consume sufficient dietary antioxidants
- nutritional supplements or topical preparations based on the
Thione Complex offer additional protection.