Introducing the Thione Complex to the Body: The Delivery
Replication of the body’s synergistic cellular antioxidant system
coupled with an ability to manipulate the formulation depending
on the targeted application are extremely beneficial, however, the
mechanism for getting the Thione Complex into the body is
equally important. Recognizing this three-fold process, Dr. Hersh
spent several years researching and developing novel delivery mechanisms
for introducing the Thione Complex to the targeted organ.
A summary of such mechanisms follows.
When antioxidants are consumed to boost overall health, they
are usually delivered to the body in capsule form. However, a
far superior method of delivery exists, known to practitioners
as “buccal absorption.” Absorption by the lining cells in the
oral cavity is the mechanism that Thione utilizes to deliver the
Thione Complex to the body.
Ingestion of a capsule delivers the antioxidants to the small
intestine. The capsule itself protects the active ingredients
from being denatured or inactivated by the gastric acids, but
then has to dissolve in order to permit the active ingredients
to be absorbed by the small intestine. In some cases, the capsule
does not dissolve and instead travels through the entire gut from
which it is later expelled without delivering the active ingredients.
When the capsule does dissolve properly, the active ingredients
are released into the small intestine. At this point, two reactions
occur. First, some of the active ingredients remain in the lumen
of the gut while others are absorbed by the lining cells of the
small intestine (allowing it to retain some of the active ingredients
for its own use). Thereafter, the remainder of the active ingredients
are transported through the portal vein to the liver. The liver
then utilizes the portion of the active ingredients that it needs
and releases the remaining active ingredients to the general systemic
circulation for delivery to the body’s other organs. Intestinal
absorption of antioxidants results in a lower initial peak blood
level of the antioxidants and less sustained concentrations for
continuous delivery to the other organs.
Conversely, buccal absorption of antioxidants, particularly those
contained in the Thione Complex, results both in an early
high peak blood level and then in sustained higher concentrations
for continuous delivery to all tissues. The buccal mucosal cells
in the lining tissues of the oral cavity are capable of absorbing
intact molecules, like glutathione and other ingredients contained
in the Thione Complex, via various physiologic transport
mechanisms. Once absorbed by these cells, these compounds are
picked up and transported in the blood by the systemic circulation
to all the organs of the body. Thus, unlike intestinal absorption,
when the active ingredients are delivered to the body through
buccal absorption, all of the tissues, the major organs and the
body fluids receive their proportionate amount of the antioxidants
rather than receiving “left-overs” from the small intestine and
liver. As a result, the Thione Complex can replenish and
maintain synergistic antioxidant levels in all cells and body
fluids for preventative and therapeutic functions.
In addition to providing systemic circulation of the antioxidants,
buccal absorption results in numerous oral benefits. Inflammation
is a common symptom of many oral pathologies. Through absorption
of the Thione Complex directly into the buccal mucosal cells,
inflammation can be dramatically reduced and signs and symptoms
of gingival and other oral pathologies are improved.
The skin is the largest organ in the body and thus, its surface
may be used second to buccal absorption as a major organ of absorption.
Delivery vehicles for the skin must not only protect active ingredients,
but also enhance their cutaneous absorption. When the Thione Complex
is topically absorbed into the dermal layers, the synergistic
antioxidants can directly attack and neutralize the toxic free
radicals that cause inflammation resulting in skin damage, photoaging
and similar dermatologic conditions. In many cases, the efficacy
and stability of the Thione Complex is boosted by encapsulating
the active ingredients in a protective “envelope” such as a liposome,
micelle or substitute cell membrane. Topical absorption is thus
the mechanism for delivering the Thione Complex to the oro-pharyngeal
cavity (via a tablet, oral spray, toothpaste/gum gel, floss, mouthwash)
and to the skin (via a cream, lotion, shampoo, serum or roll-on
device). Additional applications under development include delivery
of the Thione Complex via suppositories and foams through
the anal and vaginal cavities. These forms of delivery will permit
the Thione Complex to attack the inflammation in these areas
associated with a number of ano-rectal and cervico-vaginal conditions
In some instances, the Thione Complex "delivery mechanism"
is just the opposite – rather than delivering the complex to the
body, it acts as a barrier such as within a cigarette filter or
the end of the cigar by neutralizing free radicals in the smoke
before they enter the body.
Inhalation of the Thione Complex directly to the respiratory
tract through a mono-dose or multi-dose inhaler is currently being
evaluated in a clinical study. By delivering the active ingredients
directly to the lungs, it appears that the Thione Complex
can have a very positive effect on reducing certain inflammatory
pulmonary conditions, particularly those from allergens, tobacco
smoke and other environmental pollutants.
Components of the Thione Complex
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